WebPatients with trisomies progressed to malignancy after 34 months, while patients with other anomalies like t (11;14), MAF translocations, other IgH translocations, monosomy13/del (13q) after 55 months. Furthermore, the presence of cytogenetic abnormalities determined the overall survival (OS). WebDetects genetic abnormalities predictive of outcome in individuals with MM See Related Tests. Multiple myeloma (MM) is a plasma cell dyscrasia that can evolve from a premalignant monoclonal gammopathy. Prognosis often depends on the presence or absence of particular genetic markers.
Multiple myeloma: Staging and prognostic studies - Uptodate Free
Table 2 shows the association between baseline disease and patient characteristics, and primary cytogenetic abnormalities. There was no difference between the groups in the proportion with ECOG performance status ≥2 (P = 0.69) or age ≥70 years (P = 0.24). There was a male predominance among patients with … See more The study included 2027 patients, diagnosed between February 2004 and February 2024, who had a successful FISH analysis. Among these, 120 (6%) had no … See more The median follow up for the entire cohort was 4.3 (interquartile range: 2.3–6.6) years from diagnosis. Treatment data were available for 1889 patients. Among … See more The TTNT for the IgH translocation and trisomies groups is found in Supplementary Table S2. For patients treated with a PI-based regimen, there was no … See more WebApr 13, 2024 · The mission of the Public Health Genomics is to integrate advances in human genetics into public health research, policy, and programs north american flicker bird
National Center for Biotechnology Information
WebFeb 14, 2024 · In a study of trisomies in multiple myeloma in 484 patients, Rajkumar et al. reported 57% patients to have trisomy of at least one odd-numbered chromosome 3, 7, 9, … WebMar 24, 2024 · When multiple myeloma is suspected clinically, patients should be tested for the presence of M proteins using a combination of tests that should include a serum … north american flicker woodpecker