Stat6 molecular weight
WebMay 1, 2024 · Part of the Methods in Molecular Biology book series (MIMB,volume 1966) Abstract Activation of signal transducer and activator of transcription 6 (STAT6) is a key signaling pathway in macrophage function, and is required for the so-called alternative (M2) activation of macrophages. WebNov 1, 2016 · Significance. STAT6 is a transcription factor and plays a predominant role in IL-4/IL-13 and virus-mediated signaling pathways. Extensive studies have linked …
Stat6 molecular weight
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WebJul 1, 1998 · The STAT family is comprised of 6 members, STAT1–STAT6, with molecular weights ranging from 84–113 kDa; their main function is to serve as transactivators of cytokine specific genes [1]. Recently, an ∼100 kDa catfish STAT homolog was identified by screening a variety of commercially available antibodies to mammalian STAT6 [3]. WebJan 18, 2024 · HEK293 cells co-transfected by LANA-myc with full length FLAG-STAT6 or its mutants were lysed in the absence of PMSF, followed by immunoblotting against exogenous STAT6 or LANA. The potential cleavage sites of STAT6 induced by LANA are proposed based on the molecular weight of cleaved isoforms and indicated on the right panel.
WebHuman STAT6 has three isoforms; the molecular weights are 94, 82 and 74kD. The immunogen (phosphorylated peptide) is shared by these three isoforms. This antibody recognizes STAT6 Phospho (Tyr641) in all three isoforms. The predominant band detected is at 94 kD. Clone A15137E does not react with mouse. WebMyBioSource.com's STAT6 (Ab-645) Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Western Blot. ... Antigen STAT6; Molecular Weight 81,748 Da; Host Rabbit; Immunogen The antibody detects endogenous level of total STAT6 protein;
WebOct 14, 2011 · We now show that STAT6 is required for innate immune signaling in response to virus infection. Viruses or cytoplasmic nucleic acids trigger STING (also named MITA/ERIS) to recruit STAT6 to the endoplasmic reticulum, leading to STAT6 phosphorylation on Ser (407) by TBK1 and Tyr (641), independent of JAKs. … WebNumbers on the left refer to molecular weight standards. B, stabilization of dimeric STAT6. Proteins were expressed in HEG293 cells, and nuclear extracts prepared from IL-4-treated cells were subjected to DNA binding.
WebJan 6, 2011 · The smaller molecular weight LMP-1 can either be a product of the “lytic” LMP-1 ... The JAK-STAT6 signaling pathway is involved in the induction of LMP-1. (A) Immunoblot analysis of total cell extracts of the IL-4– or IL-13–treated (50 ng/mL, 30 minutes) KMH2, KMH2-EBV, and Jijoye M13 cells with antibodies specific for phospho-Tyr641 ...
WebSTAT6 is tyrosine phosphorylated (Tyr641) in response to cellular interaction with IL-4. STAT6 mRNA has been detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 and Th9 immune response (2). golden cliff hotelWebSTAT6 is the only STAT protein that prefers binding to DNA motifs with a N4 spacer. One STAT6 homodimer binds a palindromic DNA motif. Each monomer binds half of the … hd.aihuishou.com/laptophd aiWebMolecular analyses have discovered that almost all SFTs harbor an NAB2-STAT6 fusion gene, which is considered specific to this tumor type. Recent studies have suggested that STAT6 immunohistochemistry is a reliable surrogate for detection of the fusion gene. Our aim was to validate these findings by examining a large number of SFT cases and a ... golden clef paperclip braceletWebSTAT6 −/− mice have increased lethality, inflammation, and cytokine production in a noninfection induced model of endotoxemia, but reduced lethality and enhanced … hd.aihuishou.com laptopWebStat6 is then released from the receptor, dimerizes, and is thought to contact the basal transcription machinery by binding to p300/CBP. While Stat6 is widely expressed in … hda homes spainWebImmunogen: Phosphorylated Human Stat6 (pY641) Application: Intracellular staining (flow cytometry) (Routinely Tested) Target Molecular Weight: 100 kDa Vol. Per Test: 20 µl RRID: … golden cliff house