WebF-box protein is the core component of the SKP1-cullin 1-F-box (SCF)-type E3 ubiquitin ligase and directly binds to substrates by various specific domains. According to the specific domains, F-box proteins are further classified into three sub-families: 1) F-box with leucine rich amino acid repeats (FBXL); 2) F-box with WD 40 amino acid repeats (FBXW); 3) F-box … WebThe F-Box domain is a 42–48 conserved amino acid domain found at the N-terminus of F-Box proteins. F-Box proteins act as modular E3 ubiquitin ligase adaptor proteins within the SCF complex responsible for phosphorylation-mediated ubiquitination. The F-Box domain mediates interaction with SKP1, which links F-Box proteins to the core ubiquitin ...
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WebDec 13, 2006 · The F-box of Rca1 is dispensable for its inhibitory effect on the APC, yet Rca1 interacts with components of the SCF and its F-box is required for a second, uncharacterized function at the G1-S transition [25, 27, 28]. Table 1 Examples of F-box proteins that function independently of Skp1. WebJan 3, 2024 · F-box proteins function as substrate adaptors for the S-phase kinase-associated protein 1 (SKP1)-cullin 1 (CUL1)-F-box protein (SCF) ubiquitin ligase … pdf转word ocr
F-box proteins and cancer: an update from functional and …
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