Webb(E) Heatmaps of ATAC-seq experiments comparing open chromatin patterns in WT and SATB1KO mature DA neurons (ATAC-seq was done in independent triplicates). (F) The . CDKN1A. gene overlaid with ATAC-seq enrichment tracks from WT and SATB1KO DA neurons as well as SATB1 ChIP-seq from WT DA neurons. ∗∗p < 0.01; ∗∗∗p < 0.001; n.s., … Webb21 dec. 2024 · SATB1 functions as a protein platform to recruit multiple gene regulatory proteins, standard ChIP-seq approaches cannot differentiate between genomic sites …
Guidance of regulatory T cell development by Satb1-dependent …
Webb22 sep. 2024 · Here we explored the mechanism of SATB1 orchestrating gene expression in DP cells. Single-cell RNA sequencing shows that Satb1 deletion changes the cell identity of DP thymocytes and... Webb15 juli 2024 · Upon Alkbh1 overexpression, SATB1 ChIP-seq peak numbers increase greater than 2-fold (Fig. 3c), while overall SATB1 levels remain unchanged (Extended data Fig. 3g). The increased SATB1 peaks in Alkbh1 OE significantly intersect with differentially decreased N 6 -mA peaks ( Alkbh1 OE vs. control); greater than 50% of those intersected … tally 9 with gst download
Essential Roles of SATB1 in Specifying T Lymphocyte Subsets
Webb15 apr. 2005 · Special AT-rich binding protein 1 (SATB1) nuclear protein, expressed predominantly in T cells, regulates genes through targeting chromatin remodeling during T-cell maturation. Here we show SATB1 family protein induction during early human adult erythroid progenitor cell differentiation concomitant with ϵ -globin expression. Webb15 juli 2024 · SATB1 binding to chromatin is abolished by N 6-mA and regulated by Alkbh1. a. Annotation of SATB1 ChIP-seq peaks in vector control (CT) and Alkbh1 overexpression (OE) cells by CEAS. The genomic distribution is shown above. b. Spearman correlation analysis of SATB1 ChIP-seq and N 6-mA DIP-seq reads, as well as input and IgG controls. Webb13 apr. 2024 · Assessment of single-cell gene expression (single-cell RNA sequencing) and adaptive immune receptor (AIR) sequencing (scVDJ-seq) has been invaluable in studying lymphocyte biology. Here we ... two tracks the ogemaw review