Web17 May 2024 · The strong prognostic performance of the 16-gene RS assay was confirmed in S-TRAC, and the RS assay is now supported by level IB evidence, which may help identify patients at high risk for recurrence who may derive higher absolute benefit from adjuvant therapy. Purpose: Adjuvant sunitinib prolonged disease-free survival (DFS; HR, 0.76) in … Web13 Aug 2024 · Daniel J. George, MD. Findings from the phase III S-TRAC trial led to the FDA approval of sunitinib (Sutent) in November 2024 as an adjuvant therapy for patients with renal cell carcinoma (RCC ...
Immune Biomarkers Predictive for Disease-Free Survival with …
WebDesign, setting, and participants: Data for 615 patients randomized to sunitinib (n=309) or placebo (n=306) in the S-TRAC trial. Outcome measurements and statistical analysis: … WebTrac proudly powers the recruitment for ... Queen's Building - Level 9, BRI Upper Maudlin Street Bristol BS2 8HW Contact Number 0117 34 25000 (option 1) Find out more Jobs Website Vacancy status: Open Ref: 387-TS-6212-EW Vacancy ID: 5207281. Trial Coordinator Accepting applications until: 08-May-2024 23:59 Vacancy status: Open Accepting ... nicole jolly wtby ct facebook
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Web10 Oct 2016 · In this randomized, double-blind, phase 3 trial, we assigned 615 patients with locoregional, high-risk clear-cell renal-cell carcinoma to receive either sunitinib (50 mg per … Web15 Dec 2024 · Only one trial (S-TRAC) provided evidence for improved DFS with sunitinib but without an overall survival (OS) signal. Keynote-564 is the first trial of an immune checkpoint inhibitor that significantly improved DFS with adjuvant pembrolizumab, a programmed death receptor-1 antibody, in clear cell renal cell carcinoma with a high risk of relapse. Web14 Sep 2024 · Abstract. Purpose: Adjuvant sunitinib prolonged disease-free survival (DFS; HR, 0.76) in patients with locoregional high-risk renal cell carcinoma (RCC) in the S-TRAC trial (ClinicalTrials.gov NCT00375674). The 16-gene Recurrence Score (RS) assay was previously developed and validated to estimate risk for disease recurrence in patients with … now i see movie