WebSynovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis. WebUncovering SUMOylation dynamics in response to DNA damage in a site ... CBP, PARP1, SetDB1, and MBD1. Whereas SUMOylated JARID1B was ubiquitylated by the SUMO-targeted ubiquitin ligase RNF4 and degraded by the proteasome in response to DNA damage, JARID1C was SUMOylated and recruited to the chromatin to demethylate histone H3K4 ...
RNF4—A Paradigm for SUMOylation‐Mediated Ubiquitination
WebSep 30, 2024 · This review will touch upon both SUMOylation and ubiquitination, and will focus on how RNF4, which is at the heart of both these PTMs, modulates cellular … WebThe precise role of SUMO proteins and associated pathways in modulating host immunity is relatively lesser known. We are beginning to appreciate that SUMOylation of immune … creative depot blog
RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes …
WebSUMOylation by SUMO2 is implicated in the degradation of misfolded ataxin-7 via RNF4 in SCA7 models. Dis Model Mech. 11 janvier 2024 Perturbation of protein homeostasis and aggregation of misfolded proteins is a major cause of many human diseases. http://genesdev.cshlp.org/content/26/11/1179 WebNov 27, 2024 · RNF4-depleted cells exposed to IR resulted in higher levels of BARD1 SUMOylation, which was further increased after inhibition of the proteasome (Fig. 5b; … creative depot stempel weihnachten