Lecithin-cholesterol acyltransferase-like 4
Nettet15. des. 2000 · Lecithin cholesterol acyltransferase was identified as a unique plasma enzyme in 1962 by Glomset [3]. Subsequent work revealed that human LCAT is a glycoprotein with a polypeptide mass of 49 kDa, augmented to around 60 kDa by a 20% carbohydrate mass. Its secondary structure contains β-sheet and α-helical elements, … NettetLecithin cholesterol acyltransferase (LCAT) is a glycoprotein that has both a phospholipase A2 and an acyltransferase action. It is essential for the normal maturation, interconversion and rearrangements of all lipoprotein classes and is involved in reverse cholesterol transport. It is synthesized by the liver and circulates in the plasma ...
Lecithin-cholesterol acyltransferase-like 4
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NettetGene ID: 104731572, updated on 4-Dec-2024. Summary Other designations. lecithin-cholesterol acyltransferase-like 4 NettetThe risk score formula was as follows: risk score = 0.06324 × relative expression of SPINK1 + 0.18856 × relative expression of TXNRD1 + (−0.15727) × relative expression of LCAT + (−0.098) × relative expression of PZP. Table 1 Univariate Cox regression analysis: P <0.05. Table 2 Coefficients of the four-gene signature for the risk score.
NettetGene ID: 103498271, updated on 17-Oct-2024. Summary Other designations. lecithin-cholesterol acyltransferase-like 4 Nettet27. nov. 2024 · Structure of lecithin:cholesterol acyltransferase with a covalent acyl-intermediate mimic and a small molecule activator reveals an active conformation …
Nettet1. nov. 1996 · The potential of a recombinant adenovirus approach for treatment of subjects with LCAT gene defects as well as patients with low plasma levels of apo A-I and HDL cholesterol is established. BACKGROUND Overexpression of human lecithin-cholesterol acyltransferase (LCAT) in transgenic mice results in an increase of the … Lecithin–cholesterol acyltransferase (LCAT, also called phosphatidylcholine–sterol O-acyltransferase) is an enzyme, in many animals including humans, that converts free cholesterol into cholesteryl ester (a more hydrophobic form of cholesterol), which is then sequestered into the core of a lipoprotein particle, eventually … Se mer Click on genes, proteins and metabolites below to link to respective articles. Se mer • Lecithin cholesterol acyltransferase deficiency • Acyl-CoA:cholesterol acyltransferase (ACAT) Se mer • Lecithin+Cholesterol+Acyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • Overview of all the structural information available in the PDB for UniProt: P04180 (Phosphatidylcholine-sterol acyltransferase) at the Se mer • Dobiásová M, Frohlich J (1999). "Advances in understanding of the role of lecithin cholesterol acyltransferase (LCAT) in cholesterol transport". Clin Chim Acta. 286 (1–2): 257–71. Se mer
NettetIntroduction. Lecithin cholesterol acyltransferase (LCAT) (EC2.3.1.43), a lipoprotein-associated enzyme, is a key player in the reverse cholesterol transport (RCT) pathway, which promotes the transfer of excess cellular cholesterol from peripheral tissues to the liver for excretion [].Genetic disorders of LCAT are associated with low levels of high …
Nettet12. apr. 2024 · Background. Haptoglobin (HP) is an antioxidant of apolipoprotein E (APOE), and previous reports have shown HP binds with APOE and amyloid beta (Aβ) to aid its clearance.A common structural variant of the HP gene distinguishes it into two alleles: HP1 and HP2.. Methods. HP genotypes were imputed in 29 cohorts from the … halone and nophicaNettetThe plasma 1ecithin:cholesterol acyltransferase reaction JOHN A. GLOMSET Department of Medicine and Regional Primate Research Center, University of Washington, Seattle, Washington 98105 ABSTRACT Evidence for the existence of a plasma lecithin : cholesterol acyltransferase is reviewed with emphasis not only on the lipid reactants, … hal on demandNettetLecithin cholesterol acyltransferase deficiency is a disorder of lipoprotein metabolism. The disease has two forms: Familial LCAT deficiency, in which there is complete LCAT deficiency, and Fish-eye disease, in which there is a partial deficiency.. Lecithin cholesterol acyltransferase catalyzes the formation of cholesterol esters in lipoproteins. halo-nb sleepsack micro fleeceNettet3. aug. 2009 · Crossref Medline Google Scholar. 29 Furbee JW, Jr., Sawyer JK, Parks JS. Lecithin:cholesterol acyltransferase deficiency increases atherosclerosis in the low density lipoprotein receptor and apolipoprotein E … burley technology solutionsNettetProtein target information for Lecithin-cholesterol acyltransferase-like 1 (thale cress). Find diseases associated with this biological target and compounds tested against it in bioassay experiments. halondrus crushing prismNettetThe plasma 1ecithin:cholesterol acyltransferase reaction JOHN A. GLOMSET Department of Medicine and Regional Primate Research Center, University of Washington, Seattle, Washington 98105 ABSTRACT Evidence for the existence of a plasma lecithin : cholesterol acyltransferase is reviewed with emphasis not only on the lipid reactants, … burley technologyNettetGene ID: 100777083, updated on 29-Aug-2024. Summary Other designations. lecithin-cholesterol acyltransferase-like 4 burley tech center