Webb6 jan. 2024 · Human HINT1 has 126 amino acids forming three helices, five β-sheets, and the rest linear sequences (DNASTAR NovaFold v15, Madison, USA). Currently, 15 HINT1 mutants have been reported to cause ARAN-NM, and protein analysis indicates that these mutants show limited localization in alpha helices (Fig. 1).The CaM-binding motif is … Webb29 juni 2024 · Introduction Autosomal recessive axonal neuropathy with neuromyotonia (ARAN-NM) is a rare disease entity linked to mutations in the histidine triad nucleotide binding protein 1 (HINT1) gene. The diagnosis and treatment of ARAN-NM are challenging. There have been few reports of ARAN-NM in East Asia. Methods A 15 …
Post-translational modification of HINT1 mediates activation
Webb20 maj 2024 · And HINT1 knockout (KO) mice were used to establish BS model, in order to investigate the role of HINT1 protein deletion. We intended to demonstrate the association between HINT1 and methamphetamine-induced reward behavior, and provide theoretical basis for the role of HINT1 in different brain regions of reward system. Webb28 jan. 2024 · The closely related enzyme HINT1 is localized in the cytosol and hydrolyzes nucleotide phosphoramidates, as well as nucleotide acyl phosphates [ 3]. hHINT1 has been shown to be essential for the activation of nucleotide phosphoramidate prodrugs (ProTides) including the first curative antiviral, sofosbuvir [ 4, 5]. pros and cons of open circulatory system
HINT1 (Histidine Triad Nucleotide-Binding Protein 1 ... - PubMed
Webb21 mars 2024 · HINT1 (Histidine Triad Nucleotide Binding Protein 1) is a Protein Coding gene. Diseases associated with HINT1 include Neuromyotonia And Axonal Neuropathy, Autosomal Recessive and … Webb15 sep. 2006 · Hint1 is a member of the evolutionarily conserved family of histidine triad proteins that acts as a haplo-insufficient tumor suppressor inducing spontaneous tumor formation in Hint +/- and Hint -/- mouse models. However, the molecular mechanisms for the tumor-suppressing activity are poorly defined. WebbHINT1 (HINT, PKCI-1, PRKCNH1) protein expression summary. We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again. HINT1. ... The Human Protein Atlas project is funded pros and cons of open concept homes