WebApr 11, 2024 · Moreover, experiments in vivo demonstrated that IDH2-knockout might not exacerbate hepatic inflammatory responses in the NASH model. ... IDH2-overexpression in lung cancer cells increases the reverse reactions of TCA cycle, promoting anaerobic glycolysis, glutaminolysis and lactate production, and reducing cellular ATP content [5]. … WebApr 13, 2024 · Moreover, glycolysis can enhance NF-κB-driven vascular inflammation via lactate signaling [52, 53]. A previous study showed that lactate can modulate the phenotype of ECs [ 54 ].
The hypoxia–lactate axis tempers inflammation - Nature
WebRecent evidence has demonstrated that the dichotomy of glycolysis supporting acute inflammatory responses and oxidative metabolism fueling sustained energy production is an oversimplification of macrophage bioenergetics, with significant cross-talk required between these metabolic pathways (49 ... WebJun 24, 2024 · In this issue of Circulation Research, Xiao et al 4 report that inflammatory stimuli increase endothelial cell glucose utilization through … download games for my phone
Glycolysis - a key player in the inflammatory response
WebJun 9, 2024 · Background Microglial activation-mediated neuroinflammation plays an important role in the progression of neurodegenerative diseases. Inflammatory activation of microglial cells is often accompanied by a metabolic switch from oxidative phosphorylation to aerobic glycolysis. However, the roles and molecular mechanisms of glycolysis in … WebJan 2, 2024 · Innate immune cells can develop exacerbated immunologic response and long-term inflammatory phenotype following brief exposure to endogenous or exogenous insults, ... Glycolysis is a major metabolic pathway and plays an important role in biosynthetic pathways. In this pathway, glucose is converted to pyruvate in the cytoplasm … WebJul 1, 2024 · Immune cells alter their predominant metabolic profile from mitochondrial respiration to glycolysis in AIDs. This metabolic reprogramming, known to occur in … class 10 sst papers