WebOne basic difference between antibodies and enzymes is that the former binds the complementary structure in its ground state , while enzymes bind in high energy state. In 1986 , the 1st monoclonal catalytic antibodies termed abzymes against a chemically stable analog of the transition state of a reaction were obtained Abzymes are catalytic ... Webf In 1986 , the 1st monoclonal catalytic antibodies. termed abzymes against a chemically stable analog. of the transition state of a reaction were obtained. Abzymes are catalytic antibodies having structural. complementarity for the transition state of an. enzyme catalyzed reaction. They bind strongly to the transition state with high.

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