WebMar 1, 2003 · Chloroacetaldehyde (CAA), acrolein, and phosphoramide mustard (PM) are cytotoxins, but acrolein and PM are the major toxins because of the abundance of their formation. HCY (4-hydroxy-cyclophosphamide) is formed primarily in the liver but circulates in blood, entering cells as its tautomer aldocyclophosphamide (AldoCY). WebJul 4, 2024 · Cyclophosphamide is a medication primarily used in the management and treatment of neoplasms, including multiple myeloma, sarcoma, and breast cancer. Cyclophosphamide is a nitrogen mustard …
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Cyclophosphamide (CP), also known as cytophosphane among other names, is a medication used as chemotherapy and to suppress the immune system. As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and … See more Cyclophosphamide is used to treat cancers and autoimmune diseases. It is used to quickly control the disease. Due to its toxicity, it is replaced as soon as possible by less toxic drugs. Regular and frequent laboratory … See more Like other alkylating agents, cyclophosphamide is teratogenic and contraindicated in pregnant women (pregnancy category D) … See more Oral cyclophosphamide is rapidly absorbed and then converted by mixed-function oxidase enzymes (cytochrome P450 system) in the liver to active metabolites. The main active metabolite is 4-hydroxycyclophosphamide, which exists in See more As reported by O. M. Colvin in his study of the development of cyclophosphamide and its clinical applications, Phosphoramide mustard, one of the principal toxic … See more Adverse drug reactions from cyclophosphamide are related to the cumulative medication dose and include chemotherapy-induced nausea and vomiting, bone marrow suppression, stomach ache, hemorrhagic cystitis, diarrhea, … See more The main effect of cyclophosphamide is due to its metabolite phosphoramide mustard. This metabolite is only formed in cells that have low levels of ALDH. Phosphoramide mustard forms DNA crosslinks both between and within DNA strands at See more The abbreviation CP is common, although abbreviating drug names is not best practice in medicine. See more WebCyclophosphamide, the most versatile of the nitrogen mustards, also has a place in stem cell transplantation and the therapy of autoimmune diseases. Adverse effects caused by the nitrogen mustards on the central nervous system, kidney, heart, bladder, and gonads remain important issues. unsuitable for phenylketonurics
CYCLOPHOSPHAMIDE - Mar Vista Animal Medical Center
WebMustard gas derivatives: Mechlorethamine, Cyclophosphamide, Chlorambucil, Melphalan, and Ifosfamide. Ethylenimines: Thiotepa and Hexamethylmelamine. Alkylsulfonates: … WebNitrogen mustards, a family of DNA alkylating agents, marked the start of cancer pharmacotherapy. While traditionally characterized by their dose-limiting toxic effects, nitrogen mustards have been the subject of intense research efforts, which have led to safer and more effective agents. WebOct 8, 2014 · The first time a patient was treated with cyclophosphamide, the active part of nitrogen mustard, the tumour shrank – something not even thought possible at the time. … recipes with turkey deli meat