Webcollagen, type VII, alpha 1. COL7A1 / Collagen VII is the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Collagen alpha-1(VII) chain is a protein that in humans is encoded by the COL7A1 gene. It is composed of a triple helical, collagenous domain flanked by two non-collagenous domains, and functions as an anchoring fibril between the dermal-epidermal junction in the basement membrane. Mutations in … See more Type VII collagen is composed of three main domains in the following order: a non-collagenous domain, abbreviated NC-1; a collagenous domain; and a second non-collagenous domain, NC-2. The NC-1 domain has a … See more This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified … See more Collagen, type VII, alpha 1 forms a complex network with several other proteins in the basement membrane. It has been shown to interact with laminin 5 and fibronectin, as well as collagen IV, by binding these proteins in the NC-1 domain. The stability of the … See more • GeneReviews/NCBI/NIH/UW entry on Dystrophic Epidermolysis Bullosa See more The inherited disease, dystrophic epidermolysis bullosa, is caused by recessive or dominant mutations in COL7A1. Recessive dystrophic epidermolysis bullosa, the most severe type of epidermolysis bullosa, has two subtypes, … See more • Collagen See more • Mecklenbeck S, Hammami-Hauasli N, Höpfner B, Schumann H, Kramer A, Küster W, Bruckner-Tuderman L (March 1999). "Clustering of COL7A1 mutations in exon 73: implications for mutation analysis in dystrophic epidermolysis bullosa". The Journal of … See more
Anti-Collagen VII antibody (ab198899) Abcam
WebJan 1, 2016 · Cloning of human type VII collagen: complete primary sequence of the alpha-1(VII) chain and identification of intragenic polymorphisms J Biol Chem , 269 ( 1994 ) , pp. 20256 - 20262 View PDF View article View in Scopus Google Scholar WebApr 14, 2024 · The crucial bone development-related candidate genes NK3 Homeobox 2 (NKX3.2), Wnt ligand secretion mediator (WLS), gremlin 1 (GREM1), fibroblast growth factor receptor 3 (FGFR3), hematopoietically expressed homeobox (HHEX), (collagen type XI alpha 1 chain (COL11A1), and Wnt Family Member 16 (WNT16)) were further identified … target optical near me hours
Collagen Type 7 - an overview ScienceDirect Topics
WebAlpha-1 Foundation Clinical Resource Centers (CRCs) Department of MedicineJ. Hillis … WebThe basic structural unit of collagen VI is a heterotrimer of the alpha1 (VI), alpha2 (VI), … WebEach center must meet certain criteria in order to be listed as a CRC through the … target optical new berlin hours