Cisplatin and creatinine clearance
WebThe intraperitoneal injection of cisplatin increased kidney weight, serum cystatin-c, and serum creatinine, at the same time, decreased body weight, urinary volume, urine creatinine, creatinine clearance, and renal antioxidant activity, all … Webwith three cycles of cisplatin 70 mg/qm2 on day 1 and methotrexate 40 mg/qm2 on days 8 and 15 of a 21-day cycle (CM) or three cycles of methotrexate 30 mg/qm2 on days 1, 15, and 22, vinblastine 3 mg/qm2 on days 2, 15, and 22, epirubicin 45 mg/qm2 on day 2, and cisplatin 70 mg/qm2 on day 2 of a 28-day cycle (M-VEC). Results
Cisplatin and creatinine clearance
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WebAug 31, 2024 · The recommended dose of ALIMTA when administered with cisplatin for initial treatment of locally advanced or metastatic non-squamous NSCLC in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m 2 as an intravenous infusion over 10 minutes administered prior to cisplatin … WebFeb 9, 2024 · Creatinine clearance is a measure of how well the kidneys filter creatinine out of the bloodstream for excretion in urine. Creatinine clearance is usually determined from a measurement of creatinine in a 24-hour urine sample and from a serum sample taken during the same time period. However, shorter time periods for urine samples may …
WebCisplatin-eligible subjects receive: gemcitabine 1000mg/m2 IV D1 and D8 every 21 days repeated for 4 cycles; cisplatin 70mg/m2 IV D1 and D8 every 21 days, repeated for 4 cycles. ... Glomerular filtration rate (GFR) or creatinine clearance (Ccr) ≥ 50 mL/min. (24 hour urine preferred). The cisplatin dose will be split over two days for values ... WebFeb 16, 2016 · All patients were treated with high-dose cisplatin CCRT. The main outcome parameters were nephrotoxicity (defined as creatinine clearance grade 2 or more) and …
WebNo significant relationship of serum creatinine levels, creatinine clearance levels, or of their increments or decrements to cisplatin dose intensity or accumulated dose were found. These levels also did not correlate with age, sex, comorbidity or Eastern Cooperative Oncology Group score. WebSerum creatinine, blood urea nitrogen, electrolyte, and glomerular filtration rate (GFR) were measured at baseline and days 2 and 7. Moreover, GFR was calculated based on the 24 …
WebThe manufacturer recommends withholding repeat administration of the drug until the serum creatinine concentration is ,1.5 mg/dL. Cisplatin has been suc- cessfullyadministeredtoHDpatientswithsimilartoleranceasin patients with normal renal …
WebApr 19, 2024 · Cisplatin is a heavy metal complex containing a central atom of platinum surrounded by two chloride atoms and two ammonia molecules in the cis position. It is soluble in water or saline at 1 mg/mL and in dimethylformamide at 24 mg/mL. It has a melting point of 207° C Indications & Dosage INDICATIONS Advanced Testicular Cancer how to resize field in access formWebDec 31, 2024 · The mean renal clearance of cisplatin exceeds creatinine clearance and is 62 and 50 mL/min/m 2 following administration of 100 mg/m 2 as 2-hour or 6- to 7-hour infusions, respectively. The renal clearance of free (ultrafilterable) platinum also exceeds the glomerular filtration rate indicating that cisplatin or other platinum-containing ... north dakota chinsWebExpert Answer. Q) A patient is receiving cisplatin …. A patient is receiving cisplatin. What creatinine clearance value indicates a dose adjustment is needed? A. Less than 50 … how to resize frame in opencv pythonWebJan 11, 2024 · Following 3–5 cycles of cisplatin at doses of 100–200 mg/m 2 (total cumulative dose 180–900 mg) in patients with testicular cancer, the mean decrease in … how to resize form in accessWebApr 12, 2024 · Among conventional chemotherapeutic drugs, cisplatin deserves a special mention. This drug is the most commonly used in cancer treatment and it can induce nephrotoxic side effects by tubular damage . ... Indeed, from 5% to 15% of the patients with both estimated creatinine clearance (eCrCl), expressed in milliliters/minute, ... north dakota chocolate covered potato chipsWebtrexate 41±31 g/m2, ifosfamide 39±14 g/m2, cisplatin 674±188 mg/m2) in 18 children and adolescents. The re-sults were compared with 13 normal volunteers matched for age and sex. Creatinine clearance, which was greater than 80 ml/min per 1.73 m2 in all patients, correlated with the total dose of ifosfamide (r=0.55, P<0.05) and cisplatin (r=0. ... north dakota chip programWebMeasurements of Blood Urea Nitrogen (BUN), serum creatinine and creatinine clearance should be taken before initiating cisplatin therapy, and prior to subsequent doses, as … north dakota chords