WebMar 19, 2004 · ATF6 is a key transcriptional activator of the unfolded protein response (UPR), which allows mammalian cells to maintain cellular homeostasis when they are … WebATF6 regulates ER protein folding capacity by promoting the expression of ER chaperones such as the 78-kDa glucose-regulated protein (GRP78). ER-resident chaperones like GRP78 prevent and/or resolve ER polypeptide accumulation and subsequent ER stress-induced UPR activation by folding nascent polypeptides.

Activating Transcription Factor 6 - an overview - ScienceDirect

WebATF6 is a key transcriptional activator of the unfolded protein response (UPR), which allows mammalian cells to maintain cellular homeostasis when they are subjected to a variety of … WebJun 17, 2024 · In all samples, we also noted a product at approximately 70 kDa that we designated ATF6-P which was prominent when we expressed the S1P mutant of ATF6α. … the seagull production video

ATF6 - Wikipedia

WebATF6α is constitutively expressed as pATF6α(P) (~90-kDa protein), and converted to pATF6α(N) (>50-kDa protein) in ER-stressed cells. Fig.2 Western blot analysis of mouse … WebActivating transcription factor 6 (ATF6), one of the three major ER stress transducers, has been shown to contribute to chemoresistance by altering cancer cell survival. Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncogene, and its expression has been correlated with the prognosis of patients with cancer. WebMay 31, 2024 · SQSTM1 KD (*) was the top second hit in proteomics, however, SQSTM1 KD in the K562 ATF6 reporter cell line did not render cells resistant to Ceapin treatment and retained a similar response to negative control cells. I, input; FT, flow-through; E, elution. the seagulls by michael rosen