Atad2 meijburg
WebSep 27, 2024 · Almost all of our current knowledge regarding the functions of ATAD2 derives from various cancer-related studies, which suggest a general role for ATAD2 as a pro-oncogenic factor stimulating oncogenic transcription factor activity and cell growth ( Caron et al, 2010; Han et al, 2024 ).
Atad2 meijburg
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1.1 Hybrid mismatches ATAD2 tackles tax avoidance via hybrid mismatches in affiliated relationships. Hybrid mismatches concern situations in which differences between tax systems are used with regard to the qualification of entities, instruments or permanent establishments. Hybrid mismatches may result in a … See more 2.1 Mismatch with hybrid entities There is a hybrid entity if an entity is regarded as tax transparent in one State, but as non-transparent in the other State. This may result in neither of … See more Under ATAD2, the provisions must be applied as of January 1, 2024 or January 1, 2024 (for the subject-to-tax measure). In this respect, the bill … See more WebJun 28, 2010 · ATAD2 is one of them encoding a conserved factor harbouring an AAA type ATPase domain and a bromodomain. We show here that ATAD2 is highly expressed in testis as well as in many cancers of...
WebSep 23, 2024 · ATAD2 shows a G2/M gene signature with peak expression during mitosis. We previously reported that ATAD2 is a specific marker and potent driver of cell proliferation in ovarian cancer []; however ... WebOct 18, 2024 · The Second Anti Tax Avoidance Directive (ATAD2) aims to fight these types abuse of hybrid mismatches, e.g by refusal of deduction of costs in a jurisdiction if the corresponding income is not taxable at the level of the receiving entity, or by treating a legal entity in the same manner in the jurisdictions concerned (either in all jurisdictions as tax …
WebNov 2, 2015 · Objective ATPase family, AAA domain containing 2 (ATAD2) has been found overexpressed in various cancer types and correlated with malignant status and poor prognosis. However, little is known about the clinical significance of ATAD2 in gastric cancer patients. The aim of this study was to explore the clinical and prognostic significance of … WebIn this study, we discovered a novel inhibitor (AM879) of ATAD2 employing the structure-based virtual screening approach, which exhibits moderate inhibitory activity against ATAD2 with IC 50 value of 3,565 nM against ATAD2, presenting no inhibitory activity against BRD2-4. AM879 exhibited potent antiproliferative activity in a dose- and time-dependent …
WebJan 1, 2024 · Executive summary. On 21 September 2024, the Netherlands has published draft legislation to implement specific reverse hybrid entity provisions as mandated by the European Union (EU) Anti-Tax Avoidance Directive II (ATAD II).
Webmotif specialized in acetyl-lysine recognition.1 ATAD2 has been proposed to act as a cofactor for oncogenic transcription factors such as ERα, AR, E2F, and Myc.2,3 Furthermore, we have recently reported a novel role for ATAD2 during DNA replication, uncovering interactions between ATAD2 and histone acetylation marks on newly … cpim upWebJul 1, 2024 · ATAD2 is a promising oncoprotein with tumor-promoting functions in many cancers. It is a valid cancer drug-target and a potential cancer-biomarker for multiple … cpin albania.gov.ukWebJul 1, 2024 · 1. Introduction. ATAD2 is an emerging oncoprotein, a potential biomarker, and a valid cancer drug-target [1, 2].It is a remarkably conserved protein, acts on upstream … cpim tijuanaWebAug 13, 2024 · On 8 August 2024, Bill No. 7466 (the “ Bill ”) implementing the Anti-Tax Avoidance Directive (EU) 2024/952 on hybrid mismatches (“ ATAD2 ”) into Luxembourg … cpim voWebATAD2 has been reported to play an important role in the processes of numerous cancers and validated to be a potential therapeutic target. This work is to discover potent ATAD2 … cpi napoliWebJul 1, 2024 · 1. Introduction. ATAD2 is an emerging oncoprotein, a potential biomarker, and a valid cancer drug-target [1, 2].It is a remarkably conserved protein, acts on upstream and basic cellular events [[3], [4], [5]], participates in DNA replication, activates chromatin dynamics, and gene transcription to promote carcinogenesis in multiple cancers … cpim ukWebFeb 26, 2024 · ATAD2 was related to the gender, smoking, tumor stage and lymph node metastasis in patients with lung adenocarcinoma, and ATAD2-positive lung adenocarcinoma patients were associated with a higher risk of recurrence [10]. In addition, patients with hepatocellular carcinoma, ovarian cancer, or breast cancer who expressed high levels of … cpi nam 2022